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Although single-agent cisplatin yielded few pCRs in sporadic TNBC, pilot studies of the addition of cisplatin or carboplatin to standard NACT have reported rates as high as 75%., binds and inactivates vascular endothelial growth factor 1, believed to support the growth and maintenance of tumor neovasculature necessary for survival and metastasis. As single agents, they have limited efficacy in heavily pretreated metastatic breast cancer, but greater activity has been seen in BRCA-mutation carriers, with pCR rates > 70% in small neoadjuvant trials., BRCA-mutated and sporadic TNBC have similar biologic characteristics and mRNA gene expression patterns, motivating further study of platinums in this subtype. Correlative studies to identify markers of response and resistance, including intrinsic subtype (basal-like v others), will be reported separately. The CALGB (Cancer and Leukemia Group B) 40603 trial was designed to examine the impact of adding carboplatin and/or bevacizumab to conventional NACT in TNBC on clinical activity, measured by pCR rates, and toxicity. In metastatic TNBC, addition of bevacizumab to once-per-week paclitaxel improves response rates and time to progression., Whether the addition of bevacizumab to NACT in TNBC could improve pCR rates and long-term outcomes was unknown. Smeshnie scenki pro povarov konditerov.